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At 24 hrs the plasma levels of sildenafil were even now close to 200 ng/mL, compared to somewhere around 5 ng/mL when sildenafil was dosed by yourself. This is certainly consistent with ritonavir's marked outcomes with a wide variety of P450 substrates. VIAGRA had no impact on ritonavir pharmacokinetics [see DOSAGE AND ADMINISTRATION and DRUG INTER